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Key points
Late gestation during pregnancy has been associated with a relatively high prevalence of obstructive sleep apnoea (OSA).
Intermittent hypoxia, a hallmark of OSA, could impose significant long‐term effects on somatic growth, energy homeostasis and metabolic function in offspring.
Here we show that late gestation intermittent hypoxia induces metabolic dysfunction as reflected by increased...
Late gestational sleep fragmentation (SF) is highly prevalent particularly in obese women, and induces metabolic dysfunction in adult offspring mice. SF induces activation of the integrated stress response (ISR), which might be involved in metabolic disorders. We hypothesized that adult offspring of double mutant mice (DM) involving the critical ISR genes CHOP and GADD34 would be protected from developing...
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