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The effect of androgen receptor transcriptional activation by RU58841, a nonsteroidal anti-androgen, was studied in the human prostate cancer PC3 cell line by cotransfection with wild-type androgen receptor (wt AR) and an androgen-responsive reporter (MMTV-ARE-CAT) construct. Anti-androgens, hydroxyflutamide, and Casodex, and the antiestrogen, genistein, were studied in parallel for comparison with...
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