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Microbes found on the skin are usually regarded as pathogens, potential pathogens or innocuous symbiotic organisms. Advances in microbiology and immunology are revising our understanding of the molecular mechanisms of microbial virulence and the specific events involved in the host-microbe interaction. A microbial community similarity function of skin sites was defined to analysis the topographical...
Information of the subcellular localizations of proteins is important because it can provide useful insights about their functions, as well as how and in what kind of cellular environments they interact with each other and with other molecules. Facing the explosion of newly generated protein sequences in the post genomic era, we are challenged to develop an automated method for fast and reliably annotating...
A novel representation of protein sequence, amino acid composition distribution (AACD), is introduced to perform prediction of subcellular localization in this paper. First, a protein sequence is divided equally into multiple segments. Then, amino acid composition of each segment is calculated in series. After that, each protein sequence can be represented a feature vector. Finally, feature vectors...
Evolutionary conservation estimated from a multiple sequence alignment is a powerful indicator of the functional significance of a residue, and helps to predict active sites, ligand binding sites, and protein interaction interfaces. Many algorithms that calculate conservation work well provided better and balanced alignment are used. Such a strong dependence on the alignment makes the results highly...
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