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Reactive oxygen species (ROS), generated following benzene exposure, are considered to trigger the development of hematopoietic neoplasms, although little supporting evidence has been found. In this study, we examined whether the experimental elimination of ROS generated following benzene exposure prevents the development of benzene-induced hematopoietic disorders to clarify the mechanism underlying...
Although benzene is known to induce myelotoxicity and leukemia in humans and mice, the underlying mechanisms are still controversial due to the discrepancy in reports on the effect of benzene on the cell cycle of hemopoietic stem cells. This study evaluates the cell kinetics of hemopoietic progenitor cells (CFU-GMs) in normal and p53 knock out (KO) mice after the animals had inhaled 300 ppm of benzene...
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