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The effect of mutations on the interactions between dimers in R67 dihydrofolate reductase (R67 DHFR), a tetrameric enzyme conferring resistance to trimethoprim, was investigated by site-directed mutagenesis combined with phenotypic, enzymatic, and biochemical analysis.Some 14 mutants at two positions involved in a hydrogen bond between dimers were constructed. All were shown to be dimers. However,...
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