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Tetraguanidines (1 and 2) with an aromatic multilayered structure exhibit potent binding to a specific site of DNAs with binding constants of the order of 10 7 M -1 as deduced from Scatchard analysis of ultrafiltration data and simulation of CD titration curves. NMR spectra of the complexes indicated that 1 and 2 bind DNAs sequence-specifically at the minor groove, as predicted...
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