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Multiple myeloma is a monoclonal gammopathy characterized by bone marrow infiltration by plasma cells or a biopsy‐proven plasmacytoma, monoclonal protein in serum and/or urine, and evidence of end‐organ damage (CRAB): hypercalcaemia, Renal impairment, Anaemia or Bone lesions. It accounts for 1% of all cancers and 10% of all haematological malignancies. Although recent therapeutic advances have increased...
Summary Despite the clear progress achieved in recent years in the treatment of MM, most patients eventually relapse and therefore novel therapeutic options are still necessary for these patients. In this regard, several drugs that target specific mechanisms of the tumor cells are currently being explored in the preclinical and clinical setting. This manuscripts offers a review of the rationale and...
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