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Serotonin 1B (5-HT 1B ) autoreceptors regulate release of serotonin from terminals of dorsal raphe nucleus (DRN) projections. Expression of 5-HT 1B in the DRN inversely correlates with behavioral measures of emotion, and viral-mediated overexpression of 5-HT 1B receptors in the middle DRN inversely reduces measures of fear and anxiety in unstressed rats. Because the caudal...
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