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The NH 2 -terminal domain of sonic hedgehog (residue 25-198) was expressed in both yeast and animal cells. The yeast-derived NH 2 -terminal domain of sonic hedgehog was less active by far than the animal cell-derived counterpart. The yeast-derived NH 2 -terminal domain of sonic hedgehog lacked 10 amino acids from the NH 2 -terminus. This cleavage of the yeast-derived...
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