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ObjectivePreviously, we have shown that IR impairs the vascular reactivity of the major cerebral arteries of ZO rats prior to the occurrence of Type‐II diabetes mellitus. However, the functional state of the microcirculation in the cerebral cortex is still being explored.
MethodsWe tested the local CoBF responses of 11–13‐week‐old ZO (n = 31) and control ZL (n = 32) rats to several stimuli measured...
Cortical spreading depression (CSD) is a feature of stroke pathophysiology. As stroke incidence increases with age, we have examined the effects of early aging and chronic cerebral hypoperfusion on CSD in rats.Three groups were studied: Young, 2-month-old animals; Middle-aged-2VO, subjected to 8 months of bilateral carotid occlusion from 2-month-of-age; and Middle-aged-SHAM, sham-operated. At 2- and...
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