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Abstract: The S100 fused‐type proteins (SFTPs) are thought to be involved in the barrier formation and function of the skin. Mutations in the profilaggrin gene, one of the best investigated members of this family, are known to be the major risk factors for ichthyosis vulgaris and atopic dermatitis. Recently, we identified human filaggrin‐2 as a new member of the SFTP family. To achieve further insight...
Abstract: A balanced proteolytic activity in the epidermis is vital to maintain epidermal homoeostasis and barrier function. Distinct protease‐inhibitor systems are operating in different epidermal layers. In the uppermost layer, the stratum corneum, kallikrein‐like proteases and their inhibitors are responsible for desquamation of the cornified keratinocytes, thus regulating the integrity of the...
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