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The dense extracellular matrix (ECM) in the pancreatic cancer severely hampers the penetration of nanodrugs, which causes inferior therapeutic efficacy. To address this issue, a multifunctional liposome, namely, Lip‐DTI/NO, integrating a type‐I photosensitizer DTITBT with glutathione (GSH) or heat‐responsive nitric oxide (NO) donor S‐nitroso‐N‐acetyl‐D‐penicillamine (SNAP) is constructed to deplete...
Mitochondria, which are important mediators for cancer initiation, growth, metastasis, and drug resistance, have been considered as a major target in cancer therapy. Herein, an acid‐activated mitochondria‐targeted drug nanocarrier is constructed for precise delivery of nitric oxide (NO) as an adenosine triphosphate (ATP) suppressor to amplify the therapeutic efficacy in cancer treatments. By combining...
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