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The preparation and the antibacterial activity of alaremycin derivatives such as their CF 3 -derivatives and (R)- and (S)-4-oxo-5-acetylaminohexanoic acid for the porphobilinogen synthase (PBGS), were described. The IC 50 values of the antibacterial activity of the prepared materials for the inhibitor of PBGS, were determined using PBGS assay.
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