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The biological molecule NO and its cyclic nucleotide effector molecule cGMP, are involved in a variety of biological systems. This article reviews evidence supporting a role for these molecules in signal transduction. Over the last 10 years, it has become evident that these molecules are important in Ca 2+ regulation, particularly in excitable cells. In these cells, cGMP-dependent mechanisms...
Influx of Ca 2+ induced by the synergistic action of glucagon plus vasopressin in the perfused rat liver was progressively inhibited by infusing increasing concentrations of Ni 2+ to the perfusion medium. The onset of Ca 2+ influx following vasopressin administration was delayed and inhibition occurred of both the initial rate of Ca 2+ influx as...
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