Search results for: Eva Freisinger

Items from 1 to 20 out of 56 results

article

Apixaban, edoxaban and rivaroxaban but not dabigatran are associated with higher mortality compared to vitamin‐K antagonists: A retrospective German claims data analysis

Christiane Engelbertz, Ursula Marschall, Jannik Feld, Lena Makowski, more

Journal of Internal Medicine > 296 > 4 > 362 - 376

Background Vitamin‐K antagonists (VKAs) have widely been replaced by non‐VKA oral anticoagulants (NOACs). This includes Austria, Germany and Switzerland, where as VKA, instead of warfarin, the much longer‐acting phenprocoumon is used, which was not compared to NOACs in clinical trials. Methods Using administrative data from a large German health insurance, we included all anticoagulation‐naïve...

article

An Extremely Stable Interprotein Tetrahedral Hg(Cys)₄ Core Forms in the Zinc Hook Domain of Rad50 Protein at Physiological pH

Marek Łuczkowski, Michał Padjasek, Józef Ba Tran, Lars Hemmingsen, more

Chemistry – A European Journal > 28 > 66 > n/a - n/a

In nature, thiolate‐based systems are the primary targets of divalent mercury (Hg^II) toxicity. The formation of Hg(Cys)_x cores in catalytic and structural protein centers mediates mercury's toxic effects and ultimately leads to cellular damage. Multiple studies have revealed distinct Hg^II‐thiolate coordination preferences, among which linear Hg^II complexes are the most commonly observed in solution...

article

An Extremely Stable Interprotein Tetrahedral Hg(Cys)₄ Core Forms in the Zinc Hook Domain of Rad50 Protein at Physiological pH

Marek Łuczkowski, Michał Padjasek, Józef Ba Tran, Lars Hemmingsen, more

Chemistry – A European Journal > 28 > 66 > n/a - n/a

Invited for the cover of this issue is the group of Artur Krężel at the University of Wrocław in collaboration with Lars Hemmingsen at The University of Copenhagen and Eva Freisinger at the University of Zürich. The image depicts the outcomes of Hg^II interactions with Rad50 protein. Read the full text of the article at 10.1002/chem.202202738.

article

Front Cover: An Extremely Stable Interprotein Tetrahedral Hg(Cys)₄ Core Forms in the Zinc Hook Domain of Rad50 Protein at Physiological pH (Chem. Eur. J. 66/2022)

Marek Łuczkowski, Michał Padjasek, Józef Ba Tran, Lars Hemmingsen, more

Chemistry – A European Journal > 28 > 66 > n/a - n/a

Hg^II interacting with a naturally Zn^II‐containing Rad50 protein interface yields HgS₄ species, the strongest metal–protein interaction known to date. It also introduces the novel manifestation of Hg^II mechanism of prokaryotic and eukaryotic cells. Furthermore, the substitution of naturally occurring Zn^II possibly has an impact on the quaternary structure and the protein assembly process, thus disrupting...

article

Low rate of revascularization procedures and poor prognosis particularly in male patients with peripheral artery disease — A propensity score matched analysis

Eva Freisinger, Nasser M. Malyar, Holger Reinecke, Michael Unrath

International Journal of Cardiology > 2018 > 255 > C > 188-194

Few data discuss the impact of sex on diagnostic and therapeutic procedures and outcome of patients with peripheral artery disease (PAD).We obtained data on 41,873 PAD patients between 2009 and 2011 (including a 4-year follow-up) from the largest German public health insurance (BARMER GEK). Propensity Score Matching (PSM) was performed to evaluate the impact of sex on treatment, complications, in-hospital...

article

Further insights into the metal ion binding abilities and the metalation pathway of a plant metallothionein from Musa acuminata

Augusto C. S. Cabral, Jovana Jakovleska, Aniruddha Deb, James E. Penner-Hahn, more

JBIC Journal of Biological Inorganic Chemistry > 2018 > 23 > 1 > 91-107

The superfamily of metallothioneins (MTs) combines a diverse group of metalloproteins, sharing the characteristics of rather low molecular weight and high cysteine content. The latter provides MTs with the capability to coordinate thiophilic metal ions, in particular those with a d¹⁰ electron configuration. The sub-family of plant MT3 proteins is only poorly characterized and there is a complete lack...

article

Celebrating Helmut Sigel

Eva Freisinger, Roland K. O. Sigel

JBIC Journal of Biological Inorganic Chemistry > 2018 > 23 > 1 > 1-5

60 years dedicated to biological inorganic chemistry—a tribute to Helmut Sigel on the occasion of his 80th birthday.

article

Impact of diabetes on outcome in critical limb ischemia with tissue loss: a large-scaled routine data analysis

Eva Freisinger, Nasser M. Malyar, Holger Reinecke, Holger Lawall

Cardiovascular Diabetology > 2017 > 16 > 1 > 1-10

Background Patients with diabetes concomitant to critical limb ischemia (CLI) represent a sub-group at particular risk. Objective of this analysis is to evaluate the actual impact of diabetes on treatment, outcome, and costs in a real-world scenario in Germany. Methods We obtained routine-data on 15,332 patients with CLI with tissue loss from the largest German health insurance, BARMER GEK from...

article

Aging and Outcome in Patients With Peripheral Artery Disease and Critical Limb Ischemia

Saskia Skonetzki, Florian Lüders, Christiane Engelbertz, Nasser M. Malyar, more

Journal of the American Medical Directors Association > 2016 > 17 > 10 > 927-932

Aging of the population is one of the major challenges facing public health systems. The impact of aging on acute and long-term outcome of patients with peripheral artery disease (PAD) and critical limb ischemia (CLI) is currently not sufficiently clarified. This analysis consists of comprehensive, anonymized data obtained from the largest public health insurance in Germany.A total of 41,740 PAD patients...

article

Amputations and mortality in in-hospital treated patients with peripheral artery disease and diabetic foot syndrome

Nasser M. Malyar, Eva Freisinger, Matthias Meyborg, Florian Lüders, more

Journal of Diabetes and its Complications > 2016 > 30 > 6 > 1117-1122

The prevalence of diabetes mellitus (DM) and its associated complications such as peripheral artery disease (PAD) and diabetic foot syndrome (DFS) are increasing worldwide. We aimed to determine the contemporary acute and long-term outcome of patients with PAD and DFS in Germany.Nationwide, anonymized data of 40,335 patients hospitalized for PAD and/or DFS from the years 2009–2011 were analyzed and...

article

Acute and chronic anemia and short- and long-term outcome of patients with peripheral arterial disease and critical limb ischemia

Florian Lüders, Christiane Engelbertz, Matthias Meyborg, Eva Freisinger, more

European Journal of Internal Medicine > 2016 > 31 > C > 62-67

Evident data about the additive effect of “the fifth cardiovascular risk factor” (anemia) and peripheral arterial disease (PAD) focused on morbidity and outcome of patients with PAD are currently still missing.A total of 41,882 PAD patients were included. Of these, 5566 (13.3%) suffered from anemia. Patients with anemia were older (P<0.001), suffered more often from chronic kidney disease (P<0...

article

Oxidation of the N‐terminal domain of the wheat metallothionein E_c‐1 leads to the formation of three distinct disulfide bridges

Katsiaryna Tarasava, Serge Chesnov, Eva Freisinger

Biopolymers > 106 > 3 > 295 - 308

Metallothioneins (MTs) are low molecular weight proteins, characterized by a high cysteine content and the ability to coordinate large amounts of d¹⁰ metal ions, for example, Zn(II), Cd(II), and Cu(I), in form of metal‐thiolate clusters. Depending on intracellular conditions such as redox potential or metal ion concentrations, MTs can occur in various states ranging from the fully metal‐loaded holo‐...

article

Investigating the influence of histidine residues on the metal ion binding ability of the wheat metallothionein γ-Ec-1 domain

Katsiaryna Tarasava, Eva Freisinger

Journal of Inorganic Biochemistry > 2015 > 153 > C > 197-203

While Zn(II) and Cd(II) have similar geochemical and environmental properties, their biological properties are distinctively different as Cd(II) ions have very limited metabolic significance and are mostly even toxic, while Zn(II) ions belong to the most essential micronutrients. One of the key proteins involved in intracellular Zn(II) and Cd(II) binding are metallothioneins (MTs), small cysteine-rich...

article

Analogues of Cis‐ and Transplatin with a Rich Solution Chemistry: cis‐[PtCl₂(NH₃)(1‐MeC‐N3)] and trans‐[PtI₂(NH₃)(1‐MeC‐N3)]

Sabine Siebel, Claudia Dammann, Pablo J. Sanz Miguel, Thomas Drewello, more

Chemistry – A European Journal > 21 > 49 > 17827 - 17843

Mono(nucleobase) complexes of the general composition cis‐[PtCl₂(NH₃)L] with L=1‐methylcytosine, 1‐MeC (1 a) and L=1‐ethyl‐5‐methylcytosine, as well as trans‐[PtX₂(NH₃)(1‐MeC)] with X=I (5 a) and X=Br (5 b) have been isolated and were characterized by X‐ray crystallography. The Pt coordination occurs through the N3 atom of the cytosine in all cases. The diaqua complexes of compounds 1 a and 5 a, cis...

article

Atrial fibrillation is a risk marker for worse in-hospital and long-term outcome in patients with peripheral artery disease

Kristina Wasmer, Michael Unrath, Julia Köbe, Nasser M. Malyar, more

International Journal of Cardiology > 2015 > 199 > Complete > 223-228

To investigate the relevance of atrial fibrillation or flutter (AF) for outcome of patients who are hospitalized for peripheral artery disease (PAD) and/or critical limb ischemia (CLI).We compared baseline data, co-morbidities, procedural data as well as in-hospital and long-term outcome of 41,882 patients who were hospitalized with PAD or CLI between 2009 and 2011 according to whether they did or...

article

Preface for the JIB Special Issue for the 12th European Biological Inorganic Chemistry Conference (EuroBIC 12) in Zurich, Switzerland, August 24–28, 2014

Eva Freisinger, Roland Sigel

Journal of Inorganic Biochemistry > 2015 > 148 > C > 1

article

Connectivity patterns and rotamer states of nucleobases determine acid–base properties of metalated purine quartets

Marc Sven Lüth, Eva Freisinger, Gunnar Kampf, Marta Garijo Anorbe, more

Journal of Inorganic Biochemistry > 2015 > 148 > C > 93-104

Potentiometric pH titrations and pD dependent ¹H NMR spectroscopy have been applied to study the acidification of the exocyclic amino group of adenine (A) model nucleobases (N9 position blocked by alkyl groups) when carrying trans-a₂Pt^II (with a=NH₃ or CH₃NH₂) entities both at N1 and N7 positions. As demonstrated, in trinuclear complexes containing central A–Pt–A units, it depends on the connectivity...

article

Preface

Eva Freisinger, Roland K. O. Sigel

JBIC Journal of Biological Inorganic Chemistry > 2014 > 19 > 2 > 699-699

article

Binding of a Designed Anti‐Cancer Drug to the Central Cavity of an RNA Three‐Way Junction

Siriporn Phongtongpasuk, Susann Paulus, Joachim Schnabl, Roland K. O. Sigel, more

Angewandte Chemie > 125 > 44 > 11727 - 11730

Bei der Cokristallisation einer Y‐verzweigten RNA mit einem antitumoraktiven Di(eisen(II))‐Zylinder (grün) ergeben sich π‐Stapelwechselwirkungen zwischen dem Zylinder und den zentralen Basenpaaren der RNA. Form, Größe und kationischer Charakter des Zylinders sind der Grund für dessen perfektes Einpassen. Native Gelelektrophorese bestätigt die Stabilisierung der Y‐verzweigten RNA durch den Eisen(II)‐Zylinder.

article

Titelbild: Binding of a Designed Anti‐Cancer Drug to the Central Cavity of an RNA Three‐Way Junction (Angew. Chem. 44/2013)

Siriporn Phongtongpasuk, Susann Paulus, Joachim Schnabl, Roland K. O. Sigel, more

Angewandte Chemie > 125 > 44 > 11639 - 11639

Erkennung und Stabilisierung einer Y‐verzweigten RNA durch einen zylinderförmigen supramolekularen Dieisen(II)‐Komplex werden von R. K. O. Sigel, B. Spingler, M. J. Hannon, E. Freisinger et al. in der Zuschrift auf S. 11727 ff. beschrieben. Der potenzielle Antikrebswirkstoff passt genau in den zentralen RNA‐Hohlraum und stabilisiert die Architektur im Festkörper ebenso wie unter nativen Gelbedingungen...

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INFONA - science communication portal

Search results for: Eva Freisinger

Apixaban, edoxaban and rivaroxaban but not dabigatran are associated with higher mortality compared to vitamin‐K antagonists: A retrospective German claims data analysis

An Extremely Stable Interprotein Tetrahedral Hg(Cys)₄ Core Forms in the Zinc Hook Domain of Rad50 Protein at Physiological pH

An Extremely Stable Interprotein Tetrahedral Hg(Cys)₄ Core Forms in the Zinc Hook Domain of Rad50 Protein at Physiological pH

Front Cover: An Extremely Stable Interprotein Tetrahedral Hg(Cys)₄ Core Forms in the Zinc Hook Domain of Rad50 Protein at Physiological pH (Chem. Eur. J. 66/2022)

Low rate of revascularization procedures and poor prognosis particularly in male patients with peripheral artery disease — A propensity score matched analysis

Further insights into the metal ion binding abilities and the metalation pathway of a plant metallothionein from Musa acuminata

Celebrating Helmut Sigel

Impact of diabetes on outcome in critical limb ischemia with tissue loss: a large-scaled routine data analysis

Aging and Outcome in Patients With Peripheral Artery Disease and Critical Limb Ischemia

Amputations and mortality in in-hospital treated patients with peripheral artery disease and diabetic foot syndrome

Acute and chronic anemia and short- and long-term outcome of patients with peripheral arterial disease and critical limb ischemia

Oxidation of the N‐terminal domain of the wheat metallothionein E_c‐1 leads to the formation of three distinct disulfide bridges

Investigating the influence of histidine residues on the metal ion binding ability of the wheat metallothionein γ-Ec-1 domain

Analogues of Cis‐ and Transplatin with a Rich Solution Chemistry: cis‐[PtCl₂(NH₃)(1‐MeC‐N3)] and trans‐[PtI₂(NH₃)(1‐MeC‐N3)]

Atrial fibrillation is a risk marker for worse in-hospital and long-term outcome in patients with peripheral artery disease

Preface for the JIB Special Issue for the 12th European Biological Inorganic Chemistry Conference (EuroBIC 12) in Zurich, Switzerland, August 24–28, 2014

Connectivity patterns and rotamer states of nucleobases determine acid–base properties of metalated purine quartets

Preface

Binding of a Designed Anti‐Cancer Drug to the Central Cavity of an RNA Three‐Way Junction

Titelbild: Binding of a Designed Anti‐Cancer Drug to the Central Cavity of an RNA Three‐Way Junction (Angew. Chem. 44/2013)

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