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This paper presents a new discrete theory of median shifts. It relates the theory to the older continuum model, predicts angular variations, and also gives an accurate figure for the active area of any discrete neighbourhood, thereby making the continuum model more accurate. The work shows that at low curvature values a quadratic law applies, this being followed by the previously known linear variation...
This paper considers the problem of applying eigenstracture assignment to parameter dependant systems. The concept of modal sensitivity is introduced, and a recently presented method for the assignment of reduced sensitivity eigenstracture is presented in this context. A new proof for this method is presented, allowing greater insight into the sensitivity problem, and leading to a more flexible design...
Unwanted drug interactions with ionic currents in the heart can lead to an increased pro-arrhythmic risk to patients in the clinic. It is therefore a priority for safety pharmacology teams to detect block of cardiac ion channels, and new technologies have enabled the development of automated and high-throughput screening assays using cell lines. As a result of screening multiple ion-channels there...
To provide a broader education for Operational Research PhD students in the UK, the Engineering and Physical Sciences Research Council funds the National Taught Course Centre for Operational Research (NATCOR). This is an initiative led by six UK universities and includes a one-week, residential simulation module taught for the first time in July 2009. We describe the background to NATCOR, summarize...
An algorithm has been recently proposed by the authors for calculating a polynomial matrix singular value decomposition (SVD) based upon polynomial matrix QR decomposition. In this work we examine how this method compares to a previously proposed method of formulating this decomposition. In particular, the performance of the two methods is examined when each is used as part of a broadband multiple-input...
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