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Instabilities that are intrinsic to natural repetitive DNA sequences produce high frequencies of length changesin vivo. Triplet repeats cloned in plasmids inEscherichia coliundergo expansions and deletions, and this instability is affected by multiple factors. We show that CTG.CAG repeats in plasmids can influence the growth ofE. coli, which affects the observed stabilities. At extended growth periods,...
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