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SummaryBackground The α2 chain of laminin-2 (merosin), encoded by a gene on chromosome 6q22, is deficient in about half the cases of congenital muscular dystrophy. Diagnosis of this condition has relied on immunocytochemical analysis of the α2 chain in muscle biopsy specimens. We have observed that normal skin also expresses laminin α2 in the basement membrane at the junction of the dermis and epidermis...
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