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Background
The purpose of this study was to investigate the effects of tonsil‐derived mesenchymal stem cells (MSCs) on osteoradionecrosis (ORN).
Method
We generated a mandibular ORN rat model using a combination of 20‐Gy single‐dose irradiation and tooth extraction. Study groups were negative control (tooth extraction only), ORN group (irradiation, tooth extraction), Matrigel‐1 group (Matrigel;...
Despite the fact that the medications used to treat abnormal bone conditions often induce osteonecrosis of the jaw (ONJ), previous attempts to establish an animal model for ONJ have shown insufficient consideration for this important prerequisite for the development of the disease. The purpose of this study was to establish an animal model with the most common metabolic bone disease, osteoporosis...
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