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Comparisons of human/rat species variants of 23 dehydrogenases versus 41 entries for peptide hormones and 41 for proteases/antiproteases reveal characteristic patterns. Dehydrogenases are 'constant' (2-8% residue differences between homologues) or 'variable' (12-40% differences). Peptide hormones exhibit a wider range, with many 'strictly conserved' and others spreading upscale, while proteases/antiproteases...
The human and bovine forms of the hydrophobic 3.7 kDa surfactant polypeptide have been structurally analyzed. The polypeptide is essentially inert to enzymatic proteolysis, and methods for analysis include peptide handling in organic solvents and fragment generation by limited acid hydrolysis. The molecule exhibits N-terminal trimming, and the relative abundance of the different starting positions...
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