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Background The management of neuropathic pain (NP) is challenging despite it being the recent focus of extensive research. A number of clinical practice guidelines (CPGs) for the management of NP have been published worldwide over the past 2 decades. This study aimed to assess the quality of these CPGs. Methods We performed a systematic review of published CPGs for the management of NP. Three reviewers...
The effect of 500 μg intrathecal (i.t.) lidocaine and tocainide injected prior to unilateral sciatic nerve section on the development of autotomy behavior was examined in rats. Neither drug inhibited autotomy compared with saline controls. The effect of lidocaine and tocainide On the flexor reflex in decerebrate, spinalized rats was also examined. Both drugs at 500 μg i.t. totally blocked the flexor...
The effect of 500 μg intrathecal (i.t.) lidocaine and tocainide injected prior to unilateral sciatic nerve section on the development of autotomy behavior was examined in rats. Neither drug inhibited autotomy compared with saline controls. The effect of lidocaine and tocainide On the flexor reflex in decerebrate, spinalized rats was also examined. Both drugs at 500 μg i.t. totally blocked the flexor...
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