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Group III metabotropic glutamate receptors (mGluRs) undergo post-translational modification by SUMO in in vitro assays but the SUMOylation of full-length mGluRs in mammalian cells has not been reported. Here we investigated SUMOylation of mGluR7 in HEK293 cells and primary cortical neurons in an attempt to confirm SUMOylation and define physiological effects on mGluR7 function. Using a recombinant...
GPCR interacting scaffold protein (GISP) is a multi-domain brain-specific scaffold protein that can regulate GABA B receptor complexes by both enhancing their surface expression and by inhibiting their lysosomal degradation. GISP retards degradation of GABA B receptors through its interaction with tumour susceptibility gene 101 (TSG101), a member of the endosomal sorting complex required...
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