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Electronic supplementary material The online version of this article (https://doi.org/10.1007/s13238-018-0524-9) contains supplementary material, which is available to authorized users.
Mediator is a highly conserved large protein complex (25 proteins, >1000 kDa) and preeminently responsible for eukaryotic transcription, which contains a dissociable ‘Cdk8 module’. Although increasing evidence demonstrates that Cdk8 module plays both positive and negative roles in transcription regulation, the detailed structure, and subunit organization, molecular mechanism how it regulates transcription...
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