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Previous studies reported disruption of adenylyl cyclase (AC)-cyclic AMP (cAMP) signal transduction in brain of Alzheimer's disease (AD). We also demonstrated that basal and stimulated AC activities in the presence of calcium and calmodulin (Ca 2+ /CaM) were significantly decreased in AD parietal cortex. In the present study, we examined the amounts of Ca 2+ /CaM-sensitive...
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