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Mass spectrometry (MS) is a powerful tool to analyze complex mixtures of proteins in a high‐throughput fashion. Proteome analysis has already become a routine task in biomedical research with the emergence of proteomics core facilities in most research institutions. Post‐translational modifications (PTMs) represent a mechanism by which complex biological processes are orchestrated dynamically at the...
Mass spectrometry has rapidly evolved to become the platform of choice for proteomic analysis. While CID remains the major fragmentation method for peptide sequencing, electron transfer dissociation (ETD) is emerging as a complementary method for the characterization of peptides and post‐translational modifications (PTMs). Here, we review the evolution of ETD and some of its newer applications including...
CID has become a routine method for fragmentation of peptides in shotgun proteomics, whereas electron transfer dissociation (ETD) has been described as a preferred method for peptides carrying labile PTMs. Though both of these fragmentation techniques have their obvious advantages, they also have their own drawbacks. By combining data from CID and ETD fragmentation, some of these disadvantages can...
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