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Primary hepatocytes offer a simple in vitro model for studying biotransformation of drugs or novel chemical entities. The utility of hepatocytes for the prediction of in vivo clearance was investigated by using 16 psychopharmacons of disparate structures (aripiprazole, biperiden, carbamazepine, citalopram, clonazepam, clozapine, duloxetine, fluoxetine, haloperidol, mianserin, mirtazapine, olanzapine,...
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