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Based on our demonstration of a circadian rhythm in the human oral mucosa cell cycle, with most cells in the G 1 phase in the morning and M phase at night, we hypothesized that morning radiotherapy (RT) would lead to less oral mucositis than afternoon RT.A total of 216 patients were randomized to morning (8–10 AM) vs. afternoon (4–6 PM) RT and stratified by radiation dose, smoking status,...
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