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Cattle were immunised orally, nasally or subcutaneously with either S. typhimurium 4/74 aroA - aroD - or S. typhimurium 4/74 htrA-based live vaccines expressing Fragment C (TetC) of tetanus toxin from plasmid pTetnir15. Oral inoculation with S. typhimurium 4/74 aroA - aroD - - (pTetnir15) elicited mucosal anti-TetC IgA but no measurable systemic humoral responses to...
Salmonella aro vaccines are able to confer solid protection against homologous virulent challenge in several animal species. Calves were protected against virulent S. typhimurium challenge following administration of a single oral dose of live BRD562 vaccine. Immune responses elicited by the S. typhimurium aro vaccine strain BRD562 were studied following administration to calves by either the oral...
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