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We have studied the effects of AMPA/kainate receptor agonists on GABA A receptor subunit mRNA expression in vitro in cultured rat cerebellar granule cells (CGCs). Kainate (KA) (100 μM) and high K + (25 mM) dramatically up-regulated δ subunit mRNA expression to 500–700% of that in control cells grown in low K + (5 mM). KA or high K + had no effect on the expression of...
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