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In this study, we compared the genotoxicity and aryl hydrocarbon receptor (AhR)-dependent transcriptional changes of selected target genes in human lung epithelial A549 cells incubated for 24h, either with extractable organic matter (EOMs) from airborne particles <2.5μm (PM2.5) collected at four localities from heavily polluted areas of the Czech Republic or two representative toxic polycyclic...
An acellular assay consisting of calf thymus DNA with/without rat liver microsomal S9 fraction was used to study the genotoxicity of complex mixtures of organic air pollutants bound to size segregated aerosols by means of DNA adduct analysis. We compared the genotoxicity of the organic extracts (EOMs) from three size fractions of aerosol ranging from 0.17μm to 10μm that were collected by high volume...
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