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To overcome the low sensitivity of current breast imaging tools, new tools for breast imaging and evaluation must be developed for reliable identification and differentiation of breast masses based on stiffness. Recently, we have shown that Harmonic Motion Imaging (HMI) can be used to differentiate relative stiffness and monitor HIFU ablations in small lumpectomy human breast specimens. The objective...
Focused Ultrasound (FUS) has been shown to modulate neural activity in the brain. Our group has recently shown feasibility of FUS modulation of peripheral nerves in vivo. However, the mechanism of FUS on the peripheral nervous system (PNS) is not known and has never been imaged in vivo. In order to unveil both the mechanism as well as provide an image-guided approach to modulation monitoring, we designed...
Pancreatic ductal adenocarcinoma (PDA) has one of the lowest prognosis due to non-specific symptoms leading to late diagnosis. The tumor is characterized by an unusually dense stroma limiting chemotherapeutic perfusion. Harmonic Motion Imaging (HMI) assesses tissue mechanical properties by inducing localized oscillation resulting from a periodic acoustic radiation force. The amplitude of the displacement...
Recently, we have shown that Harmonic Motion Imaging (HMI) can be used to differentiate relative stiffness and monitor HIFU ablations in small lumpectomy human breast specimens. The objective of this study is to apply HMI on post-surgical mastectomy breast specimen to mimic the in vivo environment and characterize tumor at different depth for better tumor localization and identification before and...
The timely and accurate diagnosis of Alzheimer's Disease (AD) is important for preventing the progress of the irreversible disease. Recently, various types of imaging techniques, e.g. Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET), have been widely used for the diagnosis of AD. Despite their usefulness, the image data generated are high-dimensional and noisy which make it...
Harmonic motion imaging (HMI) is a radiation force-based elasticity imaging technique that tracks tissue harmonic displacements induced by periodic ultrasonic radiation force to assess tissue stiffness. The objective of this study was to evaluate the feasibility of HMI in pancreatic tumor detection and high-intensity focused ultrasound (HIFU) treatment monitoring. The HMI system consisted of a focused...
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