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Biomimetic Nanoparticles
In article number 2301439, Rutong Yu, Xiuping Zhou, and co‐workers construct a Trojan‐horse‐like nanoparticle system (R‐NKm@NPs), which traverses across the blood‐brain barrier (BBB) and targets glioblastoma through the natural killer (NK) cell membrane decorated with cRGD. Notably, the R‐NKm@NPs exhibit good antitumor ability by locally releasing temozolomide (TMZ) and IL‐15,...
Although the chemo‐ and immuno‐therapies have obtained good responses for several solid tumors, including those with brain metastasis, their clinical efficacy in glioblastoma (GBM) is disappointing. The lack of safe and effective delivery systems across the blood‐brain barrier (BBB) and the immunosuppressive tumor microenvironment (TME) are two main hurdles for GBM therapy. Herein, a Trojan‐horse‐like...
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