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In article number 2007215, Jian Liu, Jun Yan, and Chenxi Li develop a technique to remotely modulate glucose metabolism in vivo with a near‐infrared laser and upconversion nanoparticle‐assisted optogenetics. A new concept to treat type 2 diabetes without the bitter burden of repeated insulin injections combined with different medicines is demonstrated.
Type 2 diabetes, lowly responsive to insulin injection, is a difficult chronic disease which requires therapeutic breakthroughs. Herein, a new concept is proposed to remotely control the glucose metabolism by a near‐infrared (NIR) laser for the treatment of type 2 diabetes for the first time. This method integrates fluorescent upconversion nanoparticles with the optogenetic technique to selectively...
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