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L-Carnitine (L-C) is involved in the transport of acyl groups into mitochondria for β-oxidation, although its role in the adult brain is still uncertain. We have shown before that the uptake ofL-carnitine into cultured rat cortical neurones was dependent on temperature as well as the Na gradient and is inhibited by compounds resembling its structure, like %%-aminobutyric acid (GABA), but most potently...
l-carnitine plays a central role in mitochondrial function and is found to be differentially distributed in the brain. We have shown before that the uptake of l-carnitine into cultured rat cortical neurones was temperature-dependent, as well as potently inhibited by factors affecting the sodium gradient as well as by molecules resembling its structure, e.g. d-carnitine, acetyl-l-carnitine and γ-aminobutyric...
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