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NGF may play a role in airway inflammation and hyperresponsiveness. We studied its possible involvement in airway remodelling and report here its proliferative effect and its receptor and signalling pathways in human airway smooth muscle cells in culture (HASMC). Proliferation of HASMC induced by NGF (0.1–10 pM) was assessed by the XTT and BrdU techniques with and without kinase inhibitors. Immunoprecipitation...
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