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Progesterone-induced Xenopus laevis oocyte maturation is mediated via a plasma membrane-bound receptor and does not require gene transcription. Evidence from several species suggests that the relevant progesterone receptor is a G-protein coupled receptor (GPCR) and that a second receptor–GPR3 and/or GPR12 in mammals–tonically opposes the progesterone receptor. We have cloned a novel X. laevis GPCR,...
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