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The Toll-IL-1 receptor (TIR) superfamily, defined by the presence of an intracellular TIR domain, initiates innate immunity via NF-κB activation, leading to production of proinflammatory cytokines. ST2 is a member of the TIR family that does not activate NF-κB and has been suggested as an important effector molecule of type 2 T helper cell responses. We have recently demonstrated that the membrane...
Mediators produced by innate immune response cells such as macrophages can profoundly influence adaptive immunity. Recent studies have shown that IL-15 and IL-18 play an influential role in inflammatory response. Here I present recent data mainly from our own laboratories illustrating the importance of IL-15 and IL-18 in the induction and perpetuation of chronic inflammation during experimental and...
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