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The transcription factor nuclear factor κB (NF-κB) plays a pivotal role in immune and inflammatory responses. Activation of NF-κB requires the activity of IKK, a kinase complex that contains two catalytic subunits, IKKα and IKKβ, and a regulatory subunit IKKγ. To understand how IKK activity is regulated, we searched for IKKγ-interacting proteins by the yeast two-hybrid system. These screenings identified...
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