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In order to study the correlation between secondarystructure and bioaffinity of long and modified sequences ofp24 protein from HIV-1, three peptides containing the minimalsize epitope from region 208-217 (EAAEWDRVHP) were prepared.It was found that peptide p24-1n, an elongated nativesequence, has the lowest KD and a predominantα-helix structure in the presence of trifluoroethanol. Three peptides containing...
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