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Previous studies have demonstrated that following intratympanic gentamicin application in the guinea pigs, vestibular evoked myogenic potentials (VEMPs) were absent regardless of stimulation mode using either air-conducted sound (ACS) stimuli or galvanic vestibular stimulation (GVS). Ultrastructurally, both type I hair cells and their calyx terminals were distorted in the saccular macula. However,...
The aim of this investigation carried out with guinea pigs was to study the possible effects of a gentamicin treatment on the saccular macula and on its afferent vestibular ganglion neurons.The gentamicin-induced impairment was analyzed using vestibular-evoked myogenic potentials (VEMPs) elicited by both click and galvanic vestibular stimulations (GVS). Fifty μl of saline or gentamicin solution (40mg/ml)...
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