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Lymph node metastasis (LNM) is a significant barrier to the prognosis of patients with gastric cancer (GC). Helicobacter pylori (H. pylori)‐positive GC patients experience a higher rate of LNM than H. pylori‐negative GC patients. However, the underlying mechanism remains unclear. Based on the findings of this study, H. pylori‐positive GC patients have greater lymphangiogenesis and lymph node immunosuppression...
Therapeutic peptides have attracted increasing attention as anti‐fibrotic drug candidates. However, the rapid degradation and insufficient liver accumulation of therapeutic peptides have seriously hampered their clinical translation. Here, the use of supramolecular nanoarchitectonics is reported to fabricate nanodrugs from therapeutic peptides for treating liver fibrosis. Self‐assembling antagonist...
Triple‐negative breast cancer (TNBC) displays a highly aggressive nature that originates from a small subpopulation of TNBC stem cells (TNBCSCs), and these TNBCSCs give rise to chemoresistance, tumor metastasis, and recurrence. Unfortunately, traditional chemotherapy eradicates normal TNBC cells but fails to kill quiescent TNBCSCs. To explore a new strategy for eradicating TNBCSCs, a disulfide‐mediated...
Insufficienct T lymphocyte infiltration and unresponsiveness to immune checkpoint blockade therapy are still major difficulties for the clinical treatment of pancreatic ductal adenocarcinoma (PDAC). Although econazole has shown promise in inhibiting PDAC growth, its poor bioavailability and water solubility limit its potential as a clinical therapy for PDAC. Furthermore, the synergistic role of econazole...
Anti‐Infection Therapies
In article number 2205471, Jianqing Gao, Fangyuan Li, Daishun Ling, and co‐workers report a silver‐based enzymatic nanoadjuvant (EnzNA) by self‐assembling silver nanoclusters that can modulate intracellular and extracellular infectious microenvironments with pH discrepancy to overcome antimicrobial resistance of pathogens. The EnzNA‐mediated modulation of the infectious microenvironment...
The emergence and evolution of antimicrobial resistance (AMR) pose a significant challenge to the current arsenal to fight infection. Antibiotic adjuvants represent an appealing tactic for tackling the AMR of pathogens, however, their practical applications are greatly constrained by the harsh infectious microenvironment. Herein, it is found that silver nanoclusters (Ag NCs) can possess tunable enzymatic...
Chemo‐phototherapy has emerged as a promising approach to complement traditional cancer treatment and enhance therapeutic effects. However, it still faces the challenges of drug efflux transporter‐mediated chemoresistance and heat shock proteins (HSPs)‐mediated phototherapy tolerance, which both depend on an excessive supply of adenosine triphosphate. Therefore, manipulating energy metabolism to impair...
Near‐field radiative heat transfer (NFRHT) can exceed the blackbody radiation limit owing to the coupled evanescent waves, implying a significant potential for energy conversion and thermal management. Coupled surface plasmon polaritons (SPPs) and hyperbolic phonon polaritons (HPPs) with small ohmic losses enable a long propagation wavelength that is essential in NFRHT. However, so far, there still...
Radiative Heat Transfer
In article number 2108032, Jinlin Song, Zixue Luo, Qiang Cheng, and co‐workers measure the near‐field radiative heat transfer between graphene/hexagonal boron nitride systems, where the coupling of hyperbolic phonon polaritons and surface plasmon polaritons is examined. The largest ever radiative heat flux is achieved for a gap space of ≈400 nm, which is six times higher than...
2D materials have been interesting for applications into nanodevices due to their intriguing physical properties. In this work, four types of unique structures are designed that are composed of MXenes and C/N‐Si layers (CNSi), where MXene is sandwiched by the CNSi layers with different thicknesses, for their practical applications into integrated devices. The systematic calculations on their elastic...
Hydrogen evolution reaction (HER) is a key step for electrochemical energy conversion and storage. Developing well defined nanostructures as noble‐metal‐free electrocatalysts for HER is promising for the application of hydrogen technology. Herein, it is reported that 3D porous hierarchical CoNiP/CoxP multi‐phase heterostructure on Ni foam via an electrodeposition method followed by phosphorization...
Transition metal dichalcogenide (TMD) nanomaterials, specially MoS2, are proven to be appealing nanoagents for photothermal cancer therapies. However, the impact of the crystal phase of TMDs on their performance in photoacoustic imaging (PAI) and photothermal therapy (PTT) remains unclear. Herein, the preparation of ultrasmall single‐layer MoS2 nanodots with different phases (1T and 2H phase) is reported...
The energy transfer from plasmonic nanostructures to semiconductors has been extensively studied to enhance light‐harvesting and tailor light–matter interactions. In this study, the efficient energy transfer from an Au metasurface to monolayered MoS2 within a near‐field coupling regime is reported. The metasurface is designed and fabricated to demonstrate strong photoluminescence (PL) and cathodoluminescence...
Molecular imaging significantly transforms the field of biomedical science and facilitates the visualization, characterization, and quantification of biologic processes. However, it is still challenging to monitor cell localization in vivo, which is essential to the study of tumor metastasis and in the development of cell‐based therapies. While most conventional small‐molecule fluorescent probes cannot...
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