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In development of small artery (less than 3 mm) prostheses, non-thrombogenicity of a vascular graft is essentially required. Lining of the synthetic graft surface with endothelial cells (ECs), called hybridization , can be one of the promising methods to confer non-thrombogenicity to the graft. In a hybrid vascular graft, stable ECs adhesion on a polymer surface is required under a flow shear...
Coagulation of blood in cultured endothelial cell-coated tubes was examined using a rheological technique. Coagulation of recalcified, platelet-free plasma in contact with an endothelial cell monolayer did not occur within the experimental time period (more than 150 min). The endothelial cell surface did not activate the intrinsic coagulation reaction or the extrinsic coagulation reaction initiated...
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