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Bone loss induced by ovariectomy is due to the direct activity on bone cells and mesenchymal cells and to the dysregulated activity of bone marrow cells, including immune cells and stromal cells, but the underlying mechanisms are not completely known. Here, we demonstrate that ovariectomy induces the T‐cell co‐stimulatory cytokine LIGHT, which stimulates both osteoblastogenesis and osteoclastogenesis...
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