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GATA transcription factor family members have been found to play a critical role in the differentiation of many tissue types. For example, GATA-3 has been found to be highly correlated with estrogen receptor α (ER) expression and is emerging as one of the “master regulators” in breast ductal epithelial cell differentiation. Recently, we discovered another GATA family member highly prevalent in breast...
The trichorhinophalangeal syndrome 1 (TRPS-1) gene is a novel GATA transcription factor family member. Previously, using a gene expression profiling and immunohistochemistry (IHC) screen, we identified TRPS-1 as a highly prevalent gene in breast cancer (BC), expressed in >90% of estrogen receptor alpha (ERα)+ and ERα− BC subtypes. TRPS-1 was also shown to be expressed in prostate cancer where it...
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