Search results for: Tsutomu Shimada

Items from 1 to 20 out of 98 results

article

Association of a continuous continence self‐management program with independence in voiding behavior among stroke patients: A retrospective cohort study

Miho Shogenji, Mikako Yoshida, Koyomi Sumiya, Tsutomu Shimada, more

Neurourology and Urodynamics > 41 > 5 > 1109 - 1120

Aims Many stroke patients cannot urinate independently due to motor and cognitive dysfunctions. This study examined whether a continuous continence self‐management program during acute and convalescent phases is associated with independence in voiding behavior. Methods A retrospective cohort study was conducted among stroke patients registered in the Council of Kaga Local Stroke Network, Japan,...

article

Incidence and risk factors of neonatal hypoglycemia after ritodrine therapy in premature labor: a retrospective cohort study

Shoko Shimokawa, Akiko Sakata, Yukio Suga, Kazuya Isoda, more

Journal of Pharmaceutical Health Care and Sciences > 2019 > 5 > 1 > 1-7

Background Ritodrine hydrochloride (RD), a β2-adrenergic agonist, is widely used as a tocolytic medication to suppress premature labor, but can cause neonatal hypoglycemia, a potentially severe side effect. We examined the incidence and risk factors of neonatal hypoglycemia following maternal intravenous administration of RD. Methods This was a retrospective study of neonates, who had birth weight...

article

Multiday corticosteroids in cancer chemotherapy delay the diagnosis of and antimicrobial administration for febrile neutropenia: a double-center retrospective study

Hiroki Uda, Yukio Suga, Eriko Toriba, Angelina Yukiko Staub, more

Journal of Pharmaceutical Health Care and Sciences > 2019 > 5 > 1 > 1-8

Background Medical staff should promptly administer antimicrobials to patients with febrile neutropenia (FN) to decrease the mortality related to cancer chemotherapy. Corticosteroids, which are used in cancer chemotherapy, have a fever-suppressive effect. This effect could lead to a blunt fever response and any local signs of infection, especially in patients receiving multiday corticosteroid administration...

article

Effect of coadministration of rifampicin on the pharmacokinetics of linezolid: clinical and animal studies

Satsuki Hashimoto, Kyoko Honda, Kohei Fujita, Yuka Miyachi, more

Journal of Pharmaceutical Health Care and Sciences > 2018 > 4 > 1 > 1-9

Background Combination therapy of linezolid (LZD) and rifampicin (RFP) may be more effective than monotherapy for treating gram-positive bacterial infections, but several studies have suggested that RFP decreases LZD exposures, thereby increasing the risk of therapeutic failure and emergence of LZD-resistant strains. However, the mechanism of the drug-drug interaction between LZD and RFP is unknown...

article

Risk factors for oxaliplatin-induced vascular pain in patients with colorectal cancer and comparison of the efficacy of preventive methods

Yukio Suga, Nana Ikeda, Manami Maeda, Angelina Yukiko Staub, more

Journal of Pharmaceutical Health Care and Sciences > 2018 > 4 > 1 > 1-7

Background Vascular pain is a common adverse drug reaction in colorectal cancer patients receiving peripheral venous administration of oxaliplatin. The aim of this work was to identify risk factors for vascular pain, and to examine whether currently used treatments reduce its incidence. Methods We conducted a multicenter retrospective study in Japanese colorectal cancer patients receiving peripheral...

article

Contribution of equilibrative nucleoside transporters 1 and 2 to gemcitabine uptake in pancreatic cancer cells

Masato Hioki, Takuya Shimada, Tian Yuan, Takeo Nakanishi, more

Biopharmaceutics & Drug Disposition > 39 > 5 > 256 - 264

Hepatic arterial infusion (HAI) chemotherapy is expected to be a more effective and safer method to treat the hepatic metastasis of pancreatic cancer than intravenous (iv) administration because of higher tumor exposure and lower systemic exposure. To clarify the uptake mechanism of nucleoside anticancer drugs, including gemcitabine (GEM), in pancreatic cancer, we investigated the uptakes of radiolabeled...

article

Effect of Kaempferia parviflora extract on knee osteoarthritis

Hiroko Kobayashi, Ryo Suzuki, Kei Sato, Takatoshi Ogami, more

Journal of Natural Medicines > 2018 > 72 > 1 > 136-144

Knee osteoarthritis (OA) is becoming more prevalent worldwide due to increases in the numbers of elderly and obese patients. Currently, pharmaceutical medicines used for the treatment of OA are for symptomatic therapy and therefore new therapeutic agents are needed. Kaempferia parviflora (KP) is a plant growing naturally in Southeast Asia and has various pharmacological effects including an anti-inflammatory...

article

Drug interaction between methotrexate and salazosulfapyridine in Japanese patients with rheumatoid arthritis

Morihiro Okada, Hiroshi Fujii, Yukio Suga, Satoshi Morito, more

Journal of Pharmaceutical Health Care and Sciences > 2017 > 3 > 1 > 1-7

Background Methotrexate (MTX) and salazosulfapyridine (SASP) are disease-modifying drugs that are commonly used in the treatment of rheumatoid arthritis (RA), and combination therapy with MTX and SASP is recommended for RA patients who show an inadequate response to monotherapy with either drug. This study was designed to examine the interaction between the two drugs from the viewpoint of serum MTX...

article

Co-administration of dexamethasone increases severity and accelerates onset day of neutropenia in bladder cancer patients on methotrexate, vinblastine, adriamycin and cisplatin chemotherapy: a retrospective cohort study

Shingo Itai, Yukio Suga, Yusuke Hara, Kouji Izumi, more

Journal of Pharmaceutical Health Care and Sciences > 2017 > 3 > 1 > 1-6

Background Bladder cancer patients receiving methotrexate, vinblastine, adriamycin and cisplatin (MVAC) chemotherapy are co-administered with dexamethasone as an anti-emetic. We examined whether or not dexamethasone affects the severity and onset day of MVAC-induced severe neutropenia. Methods This was a retrospective study of bladder cancer patients treated with MVAC chemotherapy with or without...

article

Activity of daily living for Morquio A syndrome

Eriko Yasuda, Yasuyuki Suzuki, Tsutomu Shimada, Kazuki Sawamoto, more

Molecular Genetics and Metabolism > 2016 > 118 > 2 > 111-122

The aim of this study was to evaluate the activity of daily living (ADL) and surgical interventions in patients with mucopolysaccharidosis IVA (MPS IVA).The factor(s) that affect ADL are age, clinical phenotypes, surgical interventions, therapeutic effect, and body mass index.The ADL questionnaire comprises three domains: “Movement,” “Movement with cognition,” and “Cognition.” Each domain has four...

article

Effects of ethyl acetate extract of Kaempferia parviflora on brown adipose tissue

Hiroko Kobayashi, Emi Horiguchi-Babamoto, Mio Suzuki, Hiroko Makihara, more

Journal of Natural Medicines > 2016 > 70 > 1 > 54-61

We have previously reported the effects of Kaempferia parviflora (KP), including anti-obesity, preventing various metabolic diseases, and regulating differentiation of white adipose cells. In this study we used Tsumura, Suzuki, Obese Diabetes (TSOD) mice—an animal model of spontaneous obese type II diabetes—and primary brown preadipocytes to examine the effects of the ethyl acetate extract of KP (KPE)...

article

Saturable Hepatic Extraction of Gemcitabine Involves Biphasic Uptake Mediated by Nucleoside Transporters Equilibrative Nucleoside Transporter 1 and 2

Takuya Shimada, Takeo Nakanishi, Hidehiro Tajima, Maiko Yamazaki, more

Journal of Pharmaceutical Sciences > 104 > 9 > 3162 - 3169

Hepatic arterial infusion (HAI) chemotherapy with gemcitabine (GEM) is expected to be more effective and safer method to treat hepatic metastasis of pancreatic cancer compared with intravenous administration, because it affords higher tumor exposure with lower systemic exposure. Thus, a key issue for dose selection is the saturability of hepatic uptake of GEM. Therefore, we investigated GEM uptake...

article

Non-invasive pulmonary function test on Morquio patients

Francyne Kubaski, Shunji Tomatsu, Pravin Patel, Tsutomu Shimada, more

Molecular Genetics and Metabolism > 2015 > 115 > 4 > 186-192

In clinical practice, respiratory function tests are difficult to perform in Morquio syndrome patients due to their characteristic skeletal dysplasia, small body size and lack of cooperation of young patients, where in some cases, conventional spirometry for pulmonary function is too challenging. To establish feasible clinical pulmonary endpoints and determine whether age impacts lung function in...

article

Di-sulfated keratan sulfate as a novel biomarker for mucopolysaccharidosis IVA

Francyne Kubaski, Tsutomu Shimada, Shunji Tomatsu, Robert W. Mason, more

Molecular Genetics and Metabolism > 2015 > 114 > 2 > S66-S67

article

Noninvasive pulmonary function test on Morquio syndrome type A patients

Francyne Kubaski, Shunji Tomatsu, Pravin Patel, Tsutomu Shimada, more

Molecular Genetics and Metabolism > 2015 > 114 > 2 > S67

article

Novel heparan sulfate assay by using automated high throughput mass spectrometry: Application to monitoring and screening for mucopolysaccharidoses

Shunji Tomatsu, Tsutomu Shimada, William A. LaMarr, Naomi V. Vlies, more

Molecular Genetics and Metabolism > 2015 > 114 > 2 > S116

article

Impact of enzyme replacement therapy and hematopoietic stem cell therapy on growth in patients with Hunter syndrome

Shunji Tomatsu, Pravin Patel, Yasuyuki Suzuki, Hiromasa Yabe, more

Molecular Genetics and Metabolism > 2015 > 114 > 2 > S115-S116

article

Chondroitin 6-sulfate as a novel biomarker for mucopolysaccharidosis IVA and VII

Francyne Kubaski, Tsutomu Shimada, Shunji Tomatsu, Eriko Yasuda, more

Molecular Genetics and Metabolism > 2015 > 114 > 2 > S66

article

Long-term follow up of post-hematopoietic stem cell transplantation for Hurler syndrome: Clinical biochemical and pathological improvements

Shunji Tomatsu, Eriko Yasuda, Kristen Ruhnke, Tsutomu Shimada, more

Molecular Genetics and Metabolism > 2015 > 114 > 2 > S116

article

Enzyme replacement therapy in newborn mucopolysaccharidosis IVA mice: Early treatment rescues bone lesions?

Shunji Tomatsu, Adriana M. Montaño, Hirotaka Oikawa, Vu Chi Dung, more

Molecular Genetics and Metabolism > 2015 > 114 > 2 > 195-202

We treated mucopolysaccharidosis IVA (MPS IVA) mice to assess the effects of long-term enzyme replacement therapy (ERT) initiated at birth, since adult mice treated by ERT showed little improvement in bone pathology [1].To conduct ERT in newborn mice, we used recombinant human N-acetylgalactosamine-6-sulfate sulfatase (GALNS) produced in a CHO cell line. First, to observe the tissue distribution pattern,...

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INFONA - science communication portal

Search results for: Tsutomu Shimada

Association of a continuous continence self‐management program with independence in voiding behavior among stroke patients: A retrospective cohort study

Incidence and risk factors of neonatal hypoglycemia after ritodrine therapy in premature labor: a retrospective cohort study

Multiday corticosteroids in cancer chemotherapy delay the diagnosis of and antimicrobial administration for febrile neutropenia: a double-center retrospective study

Effect of coadministration of rifampicin on the pharmacokinetics of linezolid: clinical and animal studies

Risk factors for oxaliplatin-induced vascular pain in patients with colorectal cancer and comparison of the efficacy of preventive methods

Contribution of equilibrative nucleoside transporters 1 and 2 to gemcitabine uptake in pancreatic cancer cells

Effect of Kaempferia parviflora extract on knee osteoarthritis

Drug interaction between methotrexate and salazosulfapyridine in Japanese patients with rheumatoid arthritis

Co-administration of dexamethasone increases severity and accelerates onset day of neutropenia in bladder cancer patients on methotrexate, vinblastine, adriamycin and cisplatin chemotherapy: a retrospective cohort study

Activity of daily living for Morquio A syndrome

Effects of ethyl acetate extract of Kaempferia parviflora on brown adipose tissue

Saturable Hepatic Extraction of Gemcitabine Involves Biphasic Uptake Mediated by Nucleoside Transporters Equilibrative Nucleoside Transporter 1 and 2

Non-invasive pulmonary function test on Morquio patients

Di-sulfated keratan sulfate as a novel biomarker for mucopolysaccharidosis IVA

Noninvasive pulmonary function test on Morquio syndrome type A patients

Novel heparan sulfate assay by using automated high throughput mass spectrometry: Application to monitoring and screening for mucopolysaccharidoses

Impact of enzyme replacement therapy and hematopoietic stem cell therapy on growth in patients with Hunter syndrome

Chondroitin 6-sulfate as a novel biomarker for mucopolysaccharidosis IVA and VII

Long-term follow up of post-hematopoietic stem cell transplantation for Hurler syndrome: Clinical biochemical and pathological improvements

Enzyme replacement therapy in newborn mucopolysaccharidosis IVA mice: Early treatment rescues bone lesions?

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