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Localized in vivo1H NMR spectroscopy is playing an increasing role in preclinical studies, because of its ability to quantify the concentrations of up to 20 metabolites in rat brain. To assess the differences between often‐used rat strains, the neurochemical profiles of Sprague‐Dawley, Wistar and Fischer rats were determined at ultrashort TE at 16.4 T. To ascertain high‐qualitative quantification,...
In vivo 1H NMR spectroscopy was used to obtain the neurochemical profile in the posterior parts of the brain, the cerebellum and the medulla oblongata in comparison to the hippocampus and the thalamus. Using small voxel sizes between 16 and 32 μl to avoid partial volume effects, most metabolites demonstrated significant regional differences except acetate, γ‐aminobutyric acid, and phosphorylcholine...
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