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Abstract: The senescence‐accelerated prone 8 (SAMP8) mouse strain shows early cognitive loss that mimics the deterioration of learning and memory in the elderly and is widely used as an animal model of aging. SAMP8 mouse brain suffers oxidative stress, as well as tau‐ and amyloid‐related pathology. Mitochondrial dysfunction and the subsequent increase in cellular oxidative stress are central to the...
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