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Natural Cell Patches
In article number 2212748, Longjiang Zhang and co‐workers report a multifunctional nanoplatform cRGD‐PEG‐MNP (RpMP). RpMPs act like cell patches to suppress macrophage pyroptosis, thus potently ameliorating the development of atherosclerosis via targeting plaque neovascularization. Chelator‐free Gd3+‐RpMPs exhibit persistent T1‐weighted contrast‐enhanced efficiency and plaque...
Pyroptosis, characterized by inflammasome activation, membrane Gasdermin D (GSDMD)‐pore formulation, and the rapid release of inflammatory cytokines, can induce plaque instability and atherosclerosis progression. Nevertheless, insights into the precise antiatherosclerosis therapies targeting pyroptosis remain limited. Here, a novel biomedical application of natural polyphenol melanin as a theranostic...
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