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The inhibitory rod cyclic GMP-phosphodiesterase γ subunit, PDEγ, is a key component of the photoresponse and is required to support rod integrity. Pdeg tm1 /Pdeg tm1 mice that lack PDEγ due to a targeted disruption of the gene encoding PDEγ, (Pdeg) suffer from a very rapid and severe photoreceptor degeneration. Previously, deletions in the carboxyl-terminal domain...
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