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A new integrated optical and electrochemical sensor system for simultaneous monitoring of intra- and extracellular superoxide (O2-) was developed using an array-based cell chip. For in vitro assays, A172 human glioblastoma cells were transferred into the cell chip and stimulated by phorbol 12-myristate 13-acetate (PMA). Intracellular O2- generation was detected via fluorescence image analysis with...
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